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1


What is the primary function of AI in the medical imaging industry?

To improve diagnostic accuracy and patient outcomes

AI medical imaging is a method of imaging which uses Artificial Intelligence to analyze medical images with speed and precision and thus is used best for diagnosis. Pinto-Coelho L. How Artificial Intelligence Is Shaping Medical Imaging Technology: A Survey of Innovations and Applications. Bioengineering (Basel). 2023 Dec 18;10(12):1435. doi: 10.3390/bioengineering10121435. PMID: 38136026; PMCID: PMC10740686. 7

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2


Which of the following is a key benefit of AI in radiology noted in the article?

Acts as a second medical opinion

AI can act as a second medical opinion in the case of radiology, this is a benefit of using Artificial Intelligence in this process. Najjar R. Redefining Radiology: A Review of Artificial Intelligence Integration in Medical Imaging. Diagnostics (Basel). 2023 Aug 25;13(17):2760. doi: 10.3390/diagnostics13172760. PMID: 37685300; PMCID: PMC10487271. 7

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3


What does AI literacy refer to according to the article?

Understanding and knowledge of AI technology

AI literacy is defined as the knowledge and understanding of the use and risks of Artificial Intelligence. Matthias Carl Laupichler, Alexandra Aster, Jana Schirch, Tobias Raupach, Artificial intelligence literacy in higher and adult education: A scoping literature review, Computers and Education: Artificial Intelligence, Volume 3, 2022, 100101, ISSN 2666-920X, https://doi.org/10.1016/j.caeai.2022.100101.(https://www.sciencedirect.com/science/article/pii/S2666920X2200056X) 7

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4


Which factor is NOT listed as influencing the acceptability of AI among healthcare professionals?

The color of the AI machines

The color of the AI Machines do not effect nor is it listed as an influencing factor on healthcare professionals. Kimiafar K, Sarbaz M, Tabatabaei SM, Ghaddaripouri K, Mousavi AS, Raei Mehneh M, Mousavi Baigi SF. Artificial intelligence literacy among healthcare professionals and students: A systematic review. Front Health Inform. 2023; 12: 168. DOI: 10.30699/fhi.v12i0.524 7

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5


What role does social influence play in AI acceptability in healthcare according to the article?

Affects healthcare professionals’ decisions to use AI

The acceptability of AI in healthcare use determines whether healthcare professionals trust the AI enough to use it in any real capacity, Hua D, Petrina N, Young N, Cho JG, Poon SK. Understanding the factors influencing acceptability of AI in medical imaging domains among healthcare professionals: A scoping review. Artif Intell Med. 2024 Jan;147:102698. doi: 10.1016/j.artmed.2023.102698. Epub 2023 Nov 9. PMID: 38184343. 7

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6


What is a perceived threat regarding AI usage in healthcare settings?

Concerns about replacing healthcare professionals

Perceived threats regarding AI usage is primarily about AI replacing real human healthcare workers. Botha NN, Segbedzi CE, Dumahasi VK, Maneen S, Kodom RV, Tsedze IS, Akoto LA, Atsu FS, Lasim OU, Ansah EW. Artificial intelligence in healthcare: a scoping review of perceived threats to patient rights and safety. Arch Public Health. 2024 Oct 23;82(1):188. doi: 10.1186/s13690-024-01414-1. PMID: 39444019; PMCID: PMC11515716. 7

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7


According to the article, what is essential for increasing AI acceptability among medical professionals?

Designing human-centred AI systems

Designing a Human-Centered AI system will increase medical professional's trust and acceptance of AI use in healthcare by a wide margin. Hua D, Petrina N, Young N, Cho JG, Poon SK. Understanding the factors influencing acceptability of AI in medical imaging domains among healthcare professionals: A scoping review. Artif Intell Med. 2024 Jan;147:102698. doi: 10.1016/j.artmed.2023.102698. Epub 2023 Nov 9. PMID: 38184343. 7

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8


What does the 'system usage' category of AI acceptability factors include according to the article?

Factors like value proposition and integration with workflows

System usage factors include value proposition, integration with workflow in addition to other factors such as organization, ethicality, social influence, etc. Hua D, Petrina N, Young N, Cho JG, Poon SK. Understanding the factors influencing acceptability of AI in medical imaging domains among healthcare professionals: A scoping review. Artif Intell Med. 2024 Jan;147:102698. doi: 10.1016/j.artmed.2023.102698. Epub 2023 Nov 9. PMID: 38184343. 7

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9


How does ethicality impact AI acceptability among healthcare professionals?

Affects views on AI based on compatibility with professional values

This is in regards to System Usage as if the AI is able to follow ethicality, it will build trust and acceptance with healthcare professionals that the AI can operate in a human professional environment with moral and practical values. Hua D, Petrina N, Young N, Cho JG, Poon SK. Understanding the factors influencing acceptability of AI in medical imaging domains among healthcare professionals: A scoping review. Artif Intell Med. 2024 Jan;147:102698. doi: 10.1016/j.artmed.2023.102698. Epub 2023 Nov 9. PMID: 38184343. 7

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10


What methodological approach did the article emphasize for future AI acceptability studies?

Considering user experience and system integration deeply

For Artificial Intelligence to gain total acceptance by medical professionals it must furthermore be integrated into the system of regular human healthcare with regards to user experience and how the AI fits into the environment of human healthcare. Hua D, Petrina N, Young N, Cho JG, Poon SK. Understanding the factors influencing acceptability of AI in medical imaging domains among healthcare professionals: A scoping review. Artif Intell Med. 2024 Jan;147:102698. doi: 10.1016/j.artmed.2023.102698. Epub 2023 Nov 9. PMID: 38184343. 7

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11


What is the primary objective of using human embryonic stem cells in treating Parkinson’s disease?

7

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12


Which animal was used to test the STEM-PD product for safety and efficacy?

Rats

It is stated that the product was transplanted into rats for an effective, safe and ethical test of STEM-PD product. C.R. Freed, Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease?, Proc. Natl. Acad. Sci. U.S.A. 99 (4) 1755-1757, https://doi.org/10.1073/pnas.062039699 (2002). Mary B. Newman, Roy A.E. Bakay, Therapeutic Potentials of Human Embryonic Stem Cells in Parkinson’s Disease, Neurotherapeutics, Volume 5, Issue 2, 2008, Pages 237-251, ISSN 1878-7479, https://doi.org/10.1016/j.nurt.2008.02.004.(https://www.sciencedirect.com/science/article/pii/S1878747923005664) 7

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13


What was the duration of the preclinical safety study in rats mentioned in the article?

3 months

The study of the sample that was cotransplanted into rats lasted up to 3 months. Natl. Acad. Sci. U.S.A. 99 (4) 1755-1757, https://doi.org/10.1073/pnas.062039699 (2002). Mary B. Newman, Roy A.E. Bakay, Therapeutic Potentials of Human Embryonic Stem Cells in Parkinson’s Disease, Neurotherapeutics, Volume 5, Issue 2, 2008, Pages 237-251, ISSN 1878-7479, https://doi.org/10.1016/j.nurt.2008.02.004.(https://www.sciencedirect.com/science/article/pii/S1878747923005664) 7

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14


What is the name of the clinical trial phase mentioned for STEM-PD?

Phase I/IIa

It was mentioned that the clinical trials on STEM-PD was called Phase I/IIa Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD Kirkeby, Agnete et al. Cell Stem Cell, Volume 30, Issue 10, 1299 - 1314.e9 7

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15


How is the STEM-PD product manufactured?

Under GMP-compliant conditions

For the production of STEM-PD, it has to be under GMP conditions. Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD Kirkeby, Agnete et al. Cell Stem Cell, Volume 30, Issue 10, 1299 - 1314.e9 7

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16


According to the article, what confirmed the safety of the STEM-PD product in rats?

There were no adverse effects or tumor formation.

There were no indication of adverse effects and there was no tumor or biodistribution after a GLP and non-GLP test confirmed this. Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD Kirkeby, Agnete et al. Cell Stem Cell, Volume 30, Issue 10, 1299 - 1314.e9 7

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17


What key finding was noted in the efficacy study of STEM-PD in rats?

Transplanted cells reversed motor deficits in rats.

The rats which were tested were found to have their motor functions returned from the previous deficit, effectively reversing it. Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD Kirkeby, Agnete et al. Cell Stem Cell, Volume 30, Issue 10, 1299 - 1314.e9 7

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18


What specific markers were used to assess the purity of the STEM-PD batch?

FOXA2 and OTX2

The markers FOXA2 and OTX2 indicated the purity of the STEM-PD batch when they were FOXA2+ and OTX2+. Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD Kirkeby, Agnete et al. Cell Stem Cell, Volume 30, Issue 10, 1299 - 1314.e9 7

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19


What role do growth factors like FGF8b and SHH play in the manufacturing process of STEM-PD?

They are used in cell patterning for specific neural fates.

FGF8b (fibroblast growth factor 8b) and SHH (sonic hedgehog) were used in the process to determine the pattern for specific fates. Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD Kirkeby, Agnete et al. Cell Stem Cell, Volume 30, Issue 10, 1299 - 1314.e9 7

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20


What was a key outcome measured in the preclinical trials for efficacy in rats?

Recovery of motor function

The final result of the test saw the return of motor function after having previously suffering from Parkinsons thanks to the STEM-PD. Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD Kirkeby, Agnete et al. Cell Stem Cell, Volume 30, Issue 10, 1299 - 1314.e9 7

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ผลคะแนน 126.25 เต็ม 140

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