| 1 |
What is the primary function of AI in the medical imaging industry?
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To improve diagnostic accuracy and patient outcomes |
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AI in medical imaging helps analyze images faster and more accurately, aiding doctors in diagnosing diseases earlier and improving treatment decisions. |
A guide to deep learning in healthcare |
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| 2 |
Which of the following is a key benefit of AI in radiology noted in the article?
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Acts as a second medical opinion |
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AI provides an additional review of medical images, helping radiologists catch details they might miss and improving diagnostic confidence. |
Deep learning in radiology |
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| 3 |
What does AI literacy refer to according to the article?
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Understanding and knowledge of AI technology |
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AI literacy means knowing how AI works, its capabilities, limitations, and how to use it responsibly. |
What is AI Literacy? Competencies and Design Considerations |
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| 4 |
Which factor is NOT listed as influencing the acceptability of AI among healthcare professionals?
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The color of the AI machines |
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The color of AI machines doesn’t affect healthcare professionals’ acceptance; factors like trust, integration, understanding, and openness to technology matter instead. |
Digital health is a cultural transformation of traditional healthcare |
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| 5 |
What role does social influence play in AI acceptability in healthcare according to the article?
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Affects healthcare professionals’ decisions to use AI |
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Social influence—like opinions of peers and leaders—impacts whether healthcare workers feel comfortable adopting AI tools. |
Unified Theory of Acceptance and Use of Technology: A Synthesis and the Road Ahead |
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| 6 |
What is a perceived threat regarding AI usage in healthcare settings?
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Concerns about replacing healthcare professionals |
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Many worry AI might replace human jobs, causing fear and resistance among healthcare workers. |
On the ethics of algorithmic decision-making in healthcare |
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| 7 |
According to the article, what is essential for increasing AI acceptability among medical professionals?
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Designing human-centred AI systems |
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AI tools should be user-friendly and support medical professionals’ needs to encourage acceptance and effective use. |
High-performance medicine: the convergence of human and artificial intelligence |
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| 8 |
What does the 'system usage' category of AI acceptability factors include according to the article?
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Factors like value proposition and integration with workflows |
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System usage involves how well AI fits into existing work processes and its perceived usefulness to users. |
What it will take to achieve the as-yet-unfulfilled promises of health information technology |
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| 9 |
How does ethicality impact AI acceptability among healthcare professionals?
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Affects views on AI based on compatibility with professional values |
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Healthcare professionals accept AI more when it aligns with their ethical standards and professional values. |
The ethics of AI in health care: A mapping review |
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| 10 |
What methodological approach did the article emphasize for future AI acceptability studies?
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Considering user experience and system integration deeply |
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Understanding how users interact with AI and how it fits into workflows is key for successful adoption. |
Organizational issues in the implementation and adoption of health information technology innovations: an interpretative review |
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| 11 |
What is the primary objective of using human embryonic stem cells in treating Parkinson’s disease?
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To replace lost dopamine neurons. |
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Parkinson’s disease is caused by the loss of dopamine-producing neurons, so stem cells aim to restore these specific cells to improve motor function. |
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease |
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| 12 |
Which animal was used to test the STEM-PD product for safety and efficacy?
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Monkeys |
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The STEM-PD product was tested on monkeys because their brain structure and function more closely resemble humans, making them suitable for evaluating safety and efficacy in Parkinson’s disease treatment. |
Human embryonic stem cell-derived dopaminergic neurons functionally integrate into the striatum and restore motor function in non-human primates |
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| 13 |
What was the duration of the preclinical safety study in rats mentioned in the article?
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12 months |
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The preclinical safety study in rats lasted 12 months to monitor long-term effects and ensure the stability and safety of the transplanted stem cell-derived neurons. |
Human embryonic stem cell-derived dopaminergic neurons functionally integrate into the striatum and restore motor function in non-human primates |
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| 14 |
What is the name of the clinical trial phase mentioned for STEM-PD?
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Phase I/IIa |
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The STEM-PD product entered a Phase I/IIa clinical trial, which focuses on evaluating both safety and preliminary efficacy in a small group of patients. |
Human embryonic stem cell-derived dopaminergic neurons functionally integrate into the striatum and restore motor function in non-human primates |
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| 15 |
How is the STEM-PD product manufactured?
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Under GMP-compliant conditions |
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The STEM-PD product is manufactured under Good Manufacturing Practice (GMP)-compliant conditions to ensure safety, quality, and consistency for clinical use in humans. |
Human embryonic stem cell-derived dopaminergic neurons functionally integrate into the striatum and restore motor function in non-human primates |
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| 16 |
According to the article, what confirmed the safety of the STEM-PD product in rats?
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There were no adverse effects or tumor formation. |
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The study confirmed the safety of the STEM-PD product in rats by observing no tumor formation or adverse effects over a 12-month period, supporting its move to human trials. |
Human embryonic stem cell-derived dopaminergic neurons functionally integrate into the striatum and restore motor function in non-human primates |
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| 17 |
What key finding was noted in the efficacy study of STEM-PD in rats?
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Transplanted cells increased cognitive impairments. |
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The efficacy study showed that the STEM-PD cells successfully integrated into the rat brain and restored motor function, demonstrating therapeutic potential for Parkinson’s disease. |
Human embryonic stem cell-derived dopaminergic neurons functionally integrate into the striatum and restore motor function in non-human primates |
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| 18 |
What specific markers were used to assess the purity of the STEM-PD batch?
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GIRK2 and ALDH1A1 |
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GIRK2 and ALDH1A1 are specific markers for midbrain A9-type dopaminergic neurons, the subtype most affected in Parkinson’s disease. Their presence confirmed the purity and identity of the STEM-PD cell batches. |
Human embryonic stem cell-derived dopaminergic neurons functionally integrate into the striatum and restore motor function in non-human primates |
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| 19 |
What role do growth factors like FGF8b and SHH play in the manufacturing process of STEM-PD?
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They are used in cell patterning for specific neural fates. |
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FGF8b and SHH are critical in guiding human embryonic stem cells to become midbrain dopaminergic neurons, which are the specific neural cells lost in Parkinson’s disease. |
Human embryonic stem cell-derived dopaminergic neurons functionally integrate into the striatum and restore motor function in non-human primates |
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| 20 |
What was a key outcome measured in the preclinical trials for efficacy in rats?
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Recovery of motor function |
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The primary goal of the preclinical efficacy trials was to assess whether the transplanted cells could restore motor abilities lost due to dopamine neuron degeneration—mimicking Parkinson’s disease symptoms. |
Human embryonic stem cell-derived dopaminergic neurons functionally integrate into the striatum and restore motor function in non-human primates |
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